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Supplemental Material
Annual Review of Pharmacology and
Toxicology
Vol. 40: 617-647 (Volume
publication date April 2000)
(doi:10.1146/annurev.pharmtox.40.1.617)

Supplementary Table for:

Annual Review of Pharmacology and
Toxicology, 40:619-649

Haian Fu, Romesh R. Subramanian, and Shane C. Masters,
14—3-3 Proteins: Structure, Function, and Regulation

Supplement Table 14—3-3 associated proteins (references
are in parentheses)

Kinases

Phosphatases

ASK1 (1)

Cdc25(A,B,C) (2, 3)

Bcr / Bcr-Abl (4, 5)

43 kDa 5-Phosphatase (6)

CPK-1a (7)

PTPH1 (8)

Chk1 (9)

Other Enzymes

IGF-1 receptor (10, 11)

H+-ATPasea (12, 13)

KSR (14)

Hat1 complex (71)

MEKK1,2,3 (17)

Nitrate reductasea (15, 16)

MLK2 (19)

Plc1+a (18)

PCTAIRE-1 (21)

ST-IV (20)

PI 3 Kinase (23)

Tryptophan hydroxylase (22)

PKC (26, 25, 65, 66, 67)

Tyrosine hydroxylase (24)

PKUa (28)

Many plant synthetic enzymesa (27)

Raf (29, 30, 31, 32, 68, 69)

Docking and Adaptor Proteins

SDK1 (35)

A20 (33, 34)

Wee1 (37)

a -synuclein
(36)

Non-Kinase Receptors

Cbl (38, 39)

a
2-adrenergic receptor (42)

IRS-1/2 (10, 40, 41)

Glucocorticoid receptor (44)

p130(Cas) (43)

GM-CSF, IL-3, IL-5 b chain (72)

RIN1 (45)

GP1b (46)

Assorted Proteins

Transcription Factors

Adrenodoxin precursor (47)

EmBP1a (48)

Bad (49)

FKHRL1 (50)

BRF1 (51)

p53 (52)

Calmodulin (53)

hTAF(II)32 (54)

CRM1 (55)

TBP (54)

Histone (56)

TFIIB (54)

Iip35 (57)

TLX-2 (58)

Keratin 8/18 (59)

VP1a (48)

Slob (60)

Virulence Factors

G Proteins

Exoenzyme S (70, 61)

Rad (62)

Middle T antigen (63)

Rem (62)

NS2 (64)

aOriginally described for plant
proteins.

LITERATURE CITED

1. Zhang L, Chen
J, Fu H. 1999. Suppression of apoptosis signal-regulating kinase
1-induced cell death by 14-3-3 proteins. Proc. Natl. Acad. Sci.
USA 96:8511--15 [View Abstract at PubMed]

2. Peng CY,
Graves PR, Thoma RS, Wu Z, Shaw AS, et al. 1997. Mitotic and G2
checkpoint control: regulation of 14-3-3 protein binding by
phosphorylation of Cdc25C on serine-216. Science 277:1501--5
[View Abstract at PubMed]

3. Conklin DS,
Galaktionov K, Beach D. 1995. 14-3-3 proteins associate with cdc25
phosphatases. Proc. Natl. Acad. Sci. USA 92:7892--96
[View Abstract at PubMed]

4. Reuther GW, Fu
H, Cripe LD, Collier RJ, Pendergast AM. 1994. Association of the
protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3
family. Science 266:129--33 [View Abstract at PubMed]

5. Braselmann S,
McCormick F. 1995. Bcr and Raf form a complex in vivo via 14-3-3
proteins. EMBO J. 14:4839--48 [View Abstract at PubMed]

6. Campbell JK,
Gurung R, Romero S, Speed CJ, Andrews RK, et al. 1997. Activation of
the 43 kDa inositol polyphosphate 5-phosphatase by 14-3-3zeta.
Biochemistry 36:15363--70 [View Abstract at PubMed]

7. Camoni L,
Harper JF, Palmgren MG. 1998. 14-3-3 proteins activate a plant
calcium-dependent protein kinase (CDPK). FEBS Lett.
430:381--84 [View Abstract at PubMed]

8. Zhang SH,
Kobayashi R, Graves PR, Piwnica-Worms H, Tonks NK. 1997. Serine
phosphorylation-dependent association of the band 4.1-related
protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein. J.
Biol. Chem. 272:27281--87 [View Abstract at PubMed]

9. Chen L, Liu
TH, Walworth NC. 1999. Association of Chk1 with 14-3-3 proteins is
stimulated by DNA damage. Genes Dev. 13:675--85 [View Abstract at PubMed]

10. Craparo A,
Freund R, Gustafson TA. 1997. 14-3-3 (epsilon) interacts with the
insulin-like growth factor I receptor and insulin receptor substrate
I in a phosphoserine-dependent manner. J. Biol. Chem.
272:11663--69 [View Abstract at PubMed]

11. Furlanetto
RW, Dey BR, Lopaczynski W, Nissley SP. 1997. 14-3-3 proteins
interact with the insulin-like growth factor receptor but not the
insulin receptor. Biochem. J. 327:765--71 [View Abstract at PubMed]

12. Fullone MR,
Visconti S, Marra M, Fogliano V, Aducci P. 1998. Fusicoccin effect
on the in vitro interaction between plant 14-3-3 proteins and plasma
membrane H+-ATPase. J. Biol. Chem. 273:7698--702 [View Abstract at PubMed]

13. Jahn T,
Fuglsang AT, Olsson A, Bruntrup IM, Collinge DB, et al. 1997. The
14-3-3 protein interacts directly with the C-terminal region of the
plant plasma membrane H(+)-ATPase. Plant Cell 9:1805--14
[View Abstract at PubMed]

14. Xing H,
Kornfeld K, Muslin AJ. 1997. The protein kinase KSR interacts with
14-3-3 protein and Raf. Curr. Biol. 7:294--300 [View Abstract at PubMed]

15. Bachmann M,
Huber JL, Athwal GS, Wu K, Ferl RJ, et al. 1996. 14-3-3 proteins
associate with the regulatory phosphorylation site of spinach leaf
nitrate reductase in an isoform-specific manner and reduce
dephosphorylation of Ser-543 by endogenous protein phosphatases.
FEBS Lett. 398:26--30 [View Abstract at PubMed]

16. Moorhead G,
Douglas P, Morrice N, Scarabel M, Aitken A, et al. 1996.
Phosphorylated nitrate reductase from spinach leaves is inhibited by
14-3-3 proteins and activated by fusicoccin. Curr. Biol.
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17. Fanger GR,
Widmann C, Porter AC, Sather S, Johnson GL, et al. 1998. 14-3-3
proteins interact with specific MEK kinases. J. Biol. Chem.
273:3476--83 [View Abstract at PubMed]

18. Andoh T,
Kato T Jr., Matsui Y, Toh-e A. 1998. Phosphoinositide-specific
phospholipase C forms a complex with 14-3-3 proteins and is involved
in expression of UV resistance in fission yeast. Mol. Gen.
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19. Nagata K,
Puls A, Futter C, .aspenstrom P, Schaefer E, et al. 1998. The MAP
kinase kinase kinase MLK2 co-localizes with activated JNK along
microtubules and associates with kinesin superfamily motor KIF3.
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20. Gao L, Gu
XB, Yu DS, Yu RK, Zeng G. 1996. Association of a 14-3-3 protein with
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21. Sladeczek F,
Camonis JH, Burnol AF, Le Bouffant F. 1997. The Cdk-like protein
PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins.
Mol. Gen. Genet. 254:571--77 [View Abstract at PubMed]

22. Furukawa Y,
Ikuta N, Omata S, Yamauchi T, Isobe T, et al. 1993. Demonstration of
the phosphorylation-dependent interaction of tryptophan hydroxylase
with the 14-3-3 protein. Biochem. Biophys. Res. Commun.
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23.
Bonnefoy-Berard N, Liu YC, von Willebrand M, Sung A, Elly C, et al.
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association with 14-3-3 proteins in T cells. Proc. Natl. Acad.
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24. Ichimura T,
Isobe T, Okuyama T, Yamauchi T, Fujisawa H. 1987. Brain 14-3-3
protein is an activator protein that activates tryptophan
5-monooxygenase and tyrosine 3-monooxygenase in the presence of
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25. Morgan A,
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26. Toker A,
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27. Moorhead G,
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Phosphorylation-dependent interactions between enzymes of plant
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28. Zhang S,
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[View Abstract at PubMed]

29. Fu H, Xia K,
Pallas DC, Cui C, Conroy K, et al. 1994. Interaction of the protein
kinase Raf-1 with 14-3-3 proteins. Science 266:126--29
[View Abstract at PubMed]

30. Fantl WJ,
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31. Irie K,
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effects of yeast and mammalian 14-3-3 proteins on the Raf protein
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32. Freed E,
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33. Vincenz C,
Dixit VM. 1996. 14-3-3 proteins associate with A20 in an
isoform-specific manner and function both as chaperone and adapter
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34. De Valck D,
Heyninck K, Van Criekinge W, Vandenabeele P, Fiers W, et al. 1997.
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35. Megidish T,
Cooper J, Zhang L, Fu H, Hakomori S. 1998. A novel
sphingosine-dependent protein kinase (SDK1) specifically
phosphorylates certain isoforms of 14-3-3 protein. J. Biol.
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36. Ostrerova N,
Petrucelli L, Farrer M, Mehta N, Choi P, et al. 1999.
alpha-Synuclein shares physical and functional homology with 14-3-3
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37. Honda R,
Ohba Y, Yasuda H. 1997. 14-3-3 zeta protein binds to the carboxyl
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38. Liu YC, Elly
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Activation-modulated association of 14-3-3 proteins with Cbl in T
cells. J. Biol. Chem. 271:14591--95 [View Abstract at PubMed]

39. Robertson H,
Langdon WY, Thien CB, Bowtell DD. 1997. A c-Cbl yeast two hybrid
screen reveals interactions with 14-3-3 isoforms and cytoskeletal
components. Biochem. Biophys. Res. Commun. 240:46--50
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40. Ogihara T,
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41. Kosaki A,
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42. Prezeau L,
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43.
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44. Wakui H,
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62. Finlin BS,
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66. Matto-Yelin,
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67. Hausser, A.,
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68. Luo, Z. J.,
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69. Li, S.,
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70. Fu, H.,
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